Mayo Clinic

Mayo Clinic
Project #:1U01AI089859-01

Title: Bioinformatics Approach to Influenza A/H1N1 Vaccine Immune Profiling

PI: Gregory A. Poland

Mayo Clinic

Primary Projects

The HIPC Center at Mayo Clinic focuses on to creating comprehensive and innovative immune profiles utilizing systems biology and bioinformatics approaches that explain and predict variations in immune responses to influenza. These studies will characterize the human immune response before and after 2010-2011 influenza A/California/H1N1 seasonal vaccination among older adults, and will enable the discrimination of baseline versus early, mid, and late (homeostatic) innate, humoral, and cellular immune responses after immunization.

These studies will be the first systematic immune profiles and models of influenza A vaccine-specific immunogenicity using novel high dimensional technology and bioinformatics approaches, and have the potential to set the standard for analytical methods to understand complex biologic systems. Novel information describing how immune responses to inactivated influenza A/H1N1 vaccine are generated will be obtained and this information may be useful in designing new vaccines to control this deadly viral disease.

Primary Projects

Bioinformatics Approach to Influenza A/H1n1 Vaccine Immune Profiling

Project Leader: Gregory Poland

Institution: Mayo Clinic

IOF Projects

Shared HIPC Resource for Network Analysis of Vaccine Immune Response

Principal Investigator: Anne Oberg

Institution: Mayo Clinic

HIPC Database Infrastructure

Principal Investigator: Peter Li

Institution: Mayo Clinic

Investigating Correlations between the Nasal Microbiome and Immunity to LAIV

Principal Investigator: Nathaniel Lambert

Institution: Mayo Clinic

CD8+ and NK Cell miRNA Expression Patterns in Older Adults Following Influenza A Vaccination

Principal Investigator: Richard Kennedy

Institution: Mayo Clinic

U.S.-India Bilateral Collaborative Research Projects

Systems Biology Assessment of Influenza A/Ph1n1 Vaccination in an Indian Cohort

HIPC Project Leader: Richard Kennedy

HIPC Institution: Mayo Clinic

Indian Project Leader: M. Radhakrishna Pillai

Indian Institution: Rajiv Gandhi Centre for Biotechnology