Baylor Research Institute

Baylor Research Institute
Project #:1U19AI089987-01

Title: Systems Analysis of Vaccine Responses in Healthy and Hyporesponsive Humans

PI: A. Karolina Palucka

Baylor Research Institute

Primary Projects Pilot Projects IOF Projects

The HIPC Center at the Baylor Institute for Immunology Research (BIIR) focuses on analyzing the immune responses to vaccination. This will be done in several cohorts of healthy individuals and in several cohorts of hyporesponsive individuals including patients suffering from autoimmune diseases (systemic lupus erythematosus and juvenile dermatomyositis), patients suffering from end-stage renal disease, and patients who have undergone autologous hematopoietic cell transplantation. Three vaccines will be studied: 1) inactivated influenza vaccine 2) hepatitis B vaccine with alum as the traditional adjuvant (Engerix) and 3) hepatitis B vaccine with CPG-oligonucleotide (Heplisav).

Our overall goal is to apply systems biology approaches to study immune responses to vaccination in healthy and immunocompromised populations. This in turn will permit us to define vaccine responders and non-responders and develop biomarker signatures predictive of vaccine response.

Primary Projects

Systems Analysis Vaccine Responses in Healthy and Hyporesponsive Humans

Project Leader: A. Karolina Palucka

Institution: Baylor Research Institute

Vaccine Induced Activation of T Follicular Helper Cell Subsets

Project Leader: Hideki Ueno

Institution: Baylor Research Institute

Systems Biology Analysis of the Response to 2 HBV vaccines: Heplisav and Engerix

Project Leader: Robert L. Coffman

Institution: Dynavax Technologies

Systems Biology Approach to Study Influenza Vaccine in Children with Autoimmunity

Project Leader: M. Virginia Pascual

Institution: Baylor Research Institute

Systems Biology in Vaccination Post Autologous Hematopoietic Cell Transplant

Project Leader: A. Karolina Palucka

Institution: Baylor Research Institute

Clinical Samples Core

Project Leader: Joseph Fay

Institution: Baylor University Medical Center

Flow Cytometry Core

Project Leader: Holden Maecker

Institution: Stanford University

Protein Core

Project Leader: Gerard Zurawski

Institution: Baylor Research Institute

Genomics Core

Project Leader: Damien Chaussabel

Institution: Baylor Research Institute

Data Mining Core

Project Leader: Damien Chaussabel

Institution: Baylor Research Institute

Pilot Projects

Investigation of the Effects of IL-12/IL-23 Blockade on Response to Vaccination in Patients with Chronic Plaque Psoriasis

Project Leader: Alan Menter

Institution: Texas Dermatology Associates, PA & Baylor Institute for Immunology Research

Systems Analysis of Pneumococcal Vaccine Responses

Project Leader: A. Karolina Palucka

Institution: Baylor Research Institute

Deep Sequence Analysis of B-Cell Responses to Vaccines in SLE Patients with High IFNα and Low IFNα Signatures and in JDM Patients

Project Leader: Martha Zuniga

Institution: University of California Santa Cruz

IOF Projects

HIPC Web Portal

Principal Investigator: Damien Chaussabel

Institution: Baylor Research Institute

Influenza Virus Neutralization Assay

Principal Investigator: Adolfo GarcĂ­a-Sastre

Institution: Mount Sinai School of Medicine

Transcriptome Analysis by RNA Sequencing of Very Small Cell Populations: A Pilot Study of Follicular Helper T Cells

Principal Investigator: Nader Pourmand

Institution: University of California Santa Cruz

Analysis of NK Cells in Response to Vaccination with Attenuated Varicella Zoster Virus

Principal Investigator: Lewis Lanier

Institution: University of California San Francisco

Optimization and Cross-Validation of CD154 Assay for Ex Vivo Quantification and Characterization of Antigen-Specific CD4+ T Cells in the Blood

Principal Investigator: Hideko Ueno

Institution: Baylor Research Institute

HIPC Innate Immune Profiling Compendium

Principal Investigator: Damien Chaussabel

Institution: Baylor Research Institute

T Follicular Helper Responses in Distinct Vaccines

Project Leader: Hideki Ueno

Institution: Baylor Research Institute