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AWARDEES: Human Immunology Project Consortium (U19), December, 2016-January 2017

The NIAID announced that three HIPC Centers were awarded based on their proposals to RFA-AI-15-041, Human Immunology Project Consortium (U19).

Human anti-viral immune responses in tissues and circulation

HIPC Project Co-Investigators: Donna Farber

HIPC Institutions: Columbia University

Systems Immune Profiling of Divergent Responses to Infection

HIPC Project Investigators: David Hafler and Ruth Montgomery

HIPC Institutions: Yale University

Systems Biology to Identify Biomarkers of Neonatal Vaccine Immunogenicity

HIPC Project Investigator: Ofer Levy

HIPC Institutions: Boston Children’s Hospital

HIPC Subcommittee Meeting, June 7, 2016

The HIPC Steering Committee meeting was held on June 7, 2016 in Rockville, Maryland.

The session focused on progress and future directions for the Samples and Assays subcommittee and the Bioinformatics and Biostatistics subcommittee. The 3 HIPC Centers provided overviews of assays currently in use, and discussion focused on standardized approaches to protocols, analysis, and HIPC-wide initiatives. These presentations were followed by demonstrations of the HIPC website, the HIPC database, ImmuneSpace, and a discussion of HIPC Data Standards. Finally, the Bioinformatics and Biostatistics subcommittee discussed cross-center data harmonization, and the future development of data validation requirements.

The meeting was attended by HIPC primary investigators and their subcommittee representatives, NIAID management staff, and NIH intramural researchers.

ANNOUNCEMENT: 10 New HIPC studies available on ImmuneSpace, April 27, 2016

ImmuneSpace recently loaded 10 new HIPC studies, part of ImmPort Data Release 18. These studies are highlighted on the ImmuneSpace home page, and can also be easily accessed by selecting the "Recently added studies" option in the ImmuneSpace Data Finder. Among other things, these studies include a large collection of flu transcriptomics data that can be used to perform meta-analyses. For more details please look at our release notes (login required).

PUBLICATION: Standardizing Flow Cytometry Immunophenotyping Analysis from the Human ImmunoPhenotyping Consortium

HIPC members and colleagues recently presented the results of a coordinated analysis of samples across nine laboratories using standardized panels, reagents and operating procedures. The paper was published in Scientific Reports. Manual gating was performed by each site and by a central site. Automated gating algorithms were developed and tested by the FlowCAP consortium. These algorithms were able to match the performance of central manual analysis for all tested panels, exhibiting little to no bias and comparable variability. All material including data, protocols and computer code can be downloaded from ImmuneSpace (https://www.immunespace.org/ ). All automated analyses can be fully reproduced “live” using OpenCyto .

ANNOUNCEMENT: ImmuneSpace is Released to the Public, January 15, 2016

We are pleased to announce that ImmuneSpace, the HIPC Database, became officially public on January 15, 2016. As part of this release, multiple datasets from human immune profiling studies are now publicly available. The ImmuneSpace platform offers users state-of-the-art computational tools to explore studies, integrate and analyze data across assays, and perform custom analyses. Additional HIPC datasets will be added on a rolling basis. Please follow @ImmuneSpace on Twitter for updates.

PUBLICATION: Compendium of Immune Signatures Identifies Conserved and Species-Specific Biology in Response to Inflammation

As a result of a project supported by an Infrastructure and Opportunity Grant from the Human Immunology Project Consortium, Nicholas Haining and colleagues have generated a collection of 5,000 annotated, immunology-specific gene sets and have used it to uncover shared and species-specific biology in mouse and human transcriptional responses to sepsis. The paper was published in Immunity. This new collection of gene sets is available from MSigDB and can easily be used within the HIPC database, ImmuneSpace (https://www.immunespace.org/ ) using the built-in GSEA framework--simply select the "MSigDB c7" collection in the "Modules" dropdown menu. For more information on how to use the ImmuneSpace GSEA tool, please watch the tutorial.

HIPC Funding Opportunity Announcement, RFA-AI-15-041, November 18, 2015

This Funding Opportunity Announcement (FOA) on the Human Immunology Project Consortium (HIPC) solicits applications from single institutions, or consortia of institutions, to participate in a network of human immunology profiling research groups in the area of infectious diseases, including HIV. The purpose of this FOA is to characterize human immune responses/mechanisms elicited by vaccinations, adjuvants or natural infection by capitalizing on recent advances in immune profiling technologies. Studies supported under this FOA will measure the diversity and commonalities of human immune responses under a variety of conditions using high-throughput systems biology approaches coupled with detailed clinical phenotyping in well-characterized human cohorts. The long-term goal is to develop molecular signatures that define immune response categories/ fingerprints/profiles that correlate with the outcomes of vaccinations, adjuvants or natural infections in humans. An additional goal of this program is to advance research by promoting rapid public access to HIPC-supported data and results through public portals such as ImmPort and ImmuneSpace, as well as the development of new methods for data integration, analysis, presentation, and visualization to further research and development in this field. Ultimately, this foundation of knowledge can also be applied to human immune-mediated diseases, such as allergy, asthma, transplant rejection, autoimmune syndromes and other inflammatory conditions.

Applications are due March 17, 2016, and the full funding announcement can be viewed at (http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-15-041.html) .

Annual HIPC Meeting, November 18-19, 2015

The annual meeting of HIPC investigators was held on November 18-19, 2015 in Rockville, Maryland.

The 3 HIPC Centers gave presentations to introduce their recently awarded projects entitled “Dengue Human Immunology Project Consortium,” “System Biological Analyses of Innate and Adaptive Responses to Vaccination,” and “Human immune signatures of Dengue virus and Mycobacterium Tuberculosis exposure in infection, disease and vaccination.” These presentations were followed by demonstrations of the HIPC website, the HIPC database, ImmuneSpace, and a discussion of HIPC Data Standards.

The meeting also included breakout meetings of the Clinical Research Subcommittee and the Samples and Assays Subcommittee.

More than 60 participants attended the meeting, including HIPC investigators and their research teams, NIAID management staff, NIH intramural researchers, FDA scientists, and others from the immunology community.

AWARDEES: Human Immunology Project Consortium (U19), June and July, 2015

The NIAID announced that three HIPC Centers were awarded based on their proposals to RFA-AI-14-007, Human Immunology Project Consortium (U19). Additional Centers are expected to be added to the HIPC program in 2016.

Dengue Human Immunology Project Consortium (DHIPC)

HIPC Project Co-Investigators: Ana Fernandez-Sesma & Eva Harris

HIPC Institutions: Icahn School of Medicine at Mt. Sinai & University of California, Berkeley

System Biological Analyses of Innate and Adaptive Responses to Vaccination

HIPC Project Investigator: Bali Pulendran

HIPC Institutions: Emory University

Human immune signatures of Dengue virus and Mycobacterium Tuberculosis exposure in infection, disease and vaccination

HIPC Project Investigator: Alessandro Sette

HIPC Institutions: La Jolla Institute

Semi-Annual HIPC Meeting November 17-18, 2014

The semi-annual meeting of HIPC investigators was held on November 17-18, 2014 in Bethesda, Maryland.

HIPC investigators gave presentations on Highlighting Methodologies for Immune Profiling; HIPC Database and Integration of HIPC Data; Cell Specific Responses to Vaccination and/or Infection; and Immune Responses of Diverse Populations.

The meeting also included breakout sessions on CyTOF- Comparing Notes & Available Resources and B and T cell Repertoire Analysis.

More than 80 participants attended the meeting, including HIPC investigators and their research teams, NIAID management staff, NIH intramural researchers, FDA scientists, editors and staff from scientific journals, and others from the immunology community.

Semi-Annual HIPC Meeting February 19-20, 2014

The semi-annual meeting of HIPC investigators was held on February 19-20, 2014 in Bethesda, Maryland. The meeting included the Scientific Advisory Board, who reviewed and discussed HIPC progress and deliverables with the HIPC Steering Committee and with NIAID management staff.

HIPC investigators gave presentations on scientific areas of interest, the HIPC web portal and analysis resources, and data analysis tool development. A preliminary version of the HIPC Database called Immunespace was unveiled and meeting participants were able to access the database to test its functionalities. The database is expected to become publicly available in the fall of 2014.

Approximately 100 participants registered for the meeting, including HIPC investigators and their research teams, NIAID management staff, NIH intramural researchers, FDA scientists, editors and staff from scientific journals, and others from the immunology community.

Semi-Annual HIPC Meeting September 10-11, 2013

The semi-annual meeting of HIPC investigators was held on September 10-11, 2013 in Bethesda, Maryland.

HIPC investigators gave presentations on scientific areas of interest, updates on Infrastructure & Opportunities Fund (IOF) projects, and work-in-progress.

Approximately 112 participants registered for the meeting, including HIPC investigators and their research teams, NIAID management staff, NIH intramural researchers, FDA scientists, and others from the immunology community.

AWARDEES: U.S.-India Bilateral Collaborative Research Grants on Human Immune Phenotyping and Infectious Disease Project Proposals

The U.S.-India Bilateral Collaborative Research Grants on Human Immune Phenotyping and Infectious Disease program is conducted under the auspices of the Indo-U.S. Vaccine Action Program (VAP) -- a bilateral program of the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH) within the Department of Health and Human Services, United States (U.S.); and the Department of Biotechnology (DBT), Ministry of Science and Technology, Government of India; in conjunction with HIPC.

The purpose of this new program is to promote U.S.-India collaborative research on human immunophenotyping studies in the context of infectious disease and vaccine development, with Indian investigators working in collaboration with HIPC investigators. Four HIPC Centers in collaboration with five Indian institutions have been funded through this program:

B and T Cell Responses to Rotavirus Infection and Vaccination in Indian Infants

HIPC Project Leader: Harry Greenberg

HIPC Institution: Stanford University

Indian Project Leader: Gagandeep Kang

Indian Institution: Christian Medical College

Immune Signatures of Responses to Infection with Dengue Virus

HIPC Project Leader: Erol Fikrig

HIPC Institution: Yale University

Indian Project Leader: V. Ravi

Indian Institution: National Institute of Mental Health/Neurosciences, India

Systems Biology Assessment of Influenza A/Ph1n1 Vaccination in an Indian Cohort

HIPC Project Leader: Richard Kennedy

HIPC Institution: Mayo Clinic

Indian Project Leader: M. Radhakrishna Pillai

Indian Institution: Rajiv Gandhi Centre for Biotechnology

Neonatal Immune Profiles: Infections and Toxicants

HIPC Project Leader: Holden Maecker

HIPC Institution: Stanford University

Indian Project Leader: Satyajit Rath

Indian Institution: National Institute of Immunology

Innate Predictors of Adaptive BCG and HBV Vaccine-Induced Responses in Bangalore Adolescents

HIPC Project Leader: Juliana McElrath

HIPC Institution: Fred Hutchinson Cancer Research Center

Indian Project Leader: Annapurna Vyakarnam

Indian Institution: India Institute of Science

PUBLICATION PROFILE: Systems Scale Interactive Exploration Reveals Quantitative and Qualitative Differences in Response to Influenza and Pneumococcal Vaccines

NIAID-Funded HIPC Investigators Develop Interactive Web Applications to Share Data with Peers.

Investigators at the Baylor Institute for Immunology Research HIPC Center in Dallas and the Benaroya Research Institute (BRI) in Seattle have used systems immunology and genome-wide profiling to characterize the immune responses elicited by two popular vaccines, and developed interactive, web-based figures* and data exploration tools to share their findings with the broader scientific community. This work, described online in the April 18, 2013, issue of Immunity provides new insights into how vaccines confer protective immunity, which may help inform the design of vaccines for other infectious diseases and better define when vaccine boosters or adjuvants may be needed to improve protection in certain groups, such as the elderly. This study also highlights how emerging web technologies can facilitate the sharing and exploration of data generated by systems immunology research. The development of the interactive, web-based figures will allow other investigators to mine and interpret the findings. The goal of the interactive figures is to not only improve the transparency of the research, but also to share the large amount of data they generated with other scientists so that additional hypotheses could be generated and tested.

This work serves as an example of HIPC's purpose to capitalize on recent advances in immune profiling methods in order to create a novel public resource that will provide a comprehensive understanding of the human immune system and its regulation.

*: To access the interactive figures from the study, visit http://interactivefigures.com .

This bulletin was adapted from the NIAID press Release, for more information visit, http://www.niaid.nih.gov/LabsAndResources/resources/bioinformatics/Pages/vaccImmResponses.aspx .

Semi-Annual HIPC Meeting February 27-28, 2013

The semi-annual meeting of HIPC investigators was held on February 27-28, 2013 in Bethesda, Maryland. The meeting included the Scientific Advisory Board, who reviewed and discussed HIPC progress and deliverables with the HIPC Steering Committee and with NIAID management staff.

Invited guest speakers included:

  • Dr. Atul Butte (Stanford University) Leveraging the NIAID ImmPort system ( https://immport.niaid.nih.gov ) for HIPC and HIPC-Database (HIPC-DB) .
  • Dr. Juliana McElrath (Fred Hutchinson Cancer Research Center) Standardized approaches to achieve high-quality, relevant immunologic data in HIV clinical vaccine studies (HVTN: HIV Vaccine Trials Network) .
  • Dr. Richard Koup (NIAID Vaccine Research Center) Bill and Melinda Gates Foundation Comprehensive T Cell Vaccine Immune Monitoring Consortium (CTVIMC) Assays.

HIPC investigators gave presentations on scientific areas of interest, updates on Infrastructure & Opportunities Fund (IOF) projects, and work-in-progress.

Approximately 140 participants registered for the meeting, including HIPC investigators and their research teams, NIAID management staff, NIH intramural researchers, FDA scientists, and others from the immunology community.

Indo-U.S. Symposium on Human Immunology and Infectious Disease, September 4-5, 2012

Under the auspices of the Indo-U.S. Vaccine Action Program (VAP; www.niaid.nih.gov/about/organization/dmid/indo/Pages/default.aspx), an Indo-U.S. Symposium on Human Immunology and Infectious Disease was held on September 4-5, 2012 in New Delhi, India. Session topics included: Defining the Human Immune System in the Context of Infectious Disease, Human Immunity to Parasitic or Bacterial Infection/Vaccination, Tuberculosis Infection and Immunity, Immunity to Influenza Infection/Vaccination, and Molecular Mechanisms of Infectious Diseases. A panel discussion addressed the challenges and opportunities in human immunology and recommendations for future research. This symposium provided an opportunity for Indian immunology researchers to meet with U.S. scientists associated with HIPC to discuss possibilities for collaboration as part of the U.S.-India Bilateral Collaborative Research Grants on Human Immune Phenotyping and Infectious Disease.

Prior to the symposium, HIPC investigators also participated in the Indo-US Vaccine Action Program Twenty Five-Year Celebration of the VAP (1987-2012) in New Delhi, India on September 3, 2012; http://newdelhi.usembassy.gov/pr120903.html .

Semi-Annual HIPC Meeting July 9-10, 2012

The semi-annual meeting of HIPC investigators was held on July 9-10, 2012 in Bethesda, Maryland. Invited guest speakers included University of Rochester School of Medicine professor Dr. David Topham who spoke about his research as part of the University of Rochester Respiratory Pathogens Research Center. Dr. Jiankui He was invited from the South University of Science and Technology of China to inform the HIPC audience about his work on the The Human Immunome Project.

HIPC investigators gave presentations on scientific areas of interest, updates on Infrastructure & Opportunities Fund (IOF) projects, and work-in-progress.

Approximately 115 participants were in attendance, including HIPC investigators and their research teams, NIAID management staff, NIH intramural researchers, FDA scientists, and others from the immunology community.

Joint Meeting of the Centers of Excellence for Influenza Research and Surveillance (CEIRS) and the Human Immunology Project Consortium (HIPC)

On August 22, 2011 investigators from CEIRS and HIPC met at the University of Rochester Medical Center in Rochester, NY.
The goal of the meeting was to:

  • Introduce the groups performing human influenza immunology research under the CEIRS and HIPC programs and discuss the type of research that is on-going.
  • Facilitate interactions between the CEIRS and HIPC programs to leverage resources to help further human influenza immunology research.
  • Determine gap areas in the field of human influenza immunology and address possible ways to fill those gaps.

Roundtable discussions explored the following areas:

  • What are the major issues regarding immune responses to influenza or vaccine design that need resolution in the next five years?
  • What technologies or combination of technologies are required to address these issues?

For more information about the CEIRS program please visit: http://www.niaid.nih.gov/LabsAndResources/resources/ceirs/Pages/default.aspx

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