Recent Publications
- KIR+CD8+ T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19.
Li J, Zaslavsky M, Su Y, Guo J, Sikora MJ, van Unen V, Christophersen A, Chiou SH, Chen L, Li J, Ji X, Wilhelmy J, McSween AM, Palanski BA, Mallajosyula VVA, Bracey NA, Dhondalay GKR, Bhamidipati K, Pai J, Kipp LB, Dunn JE, Hauser SL, Oksenberg JR, Satpathy AT, Robinson WH, Dekker CL, Steinmetz LM, Khosla C, Utz PJ, Sollid LM, Chien YH, Heath JR, Fernandez-Becker NQ, Nadeau KC, Saligrama N, Davis MM
Science (New York, N.Y.). 2022 Apr 15
PMID: 35258337
- Fatty Acid Metabolism and T Cells in Multiple Sclerosis.
Pompura SL, Hafler DA, Dominguez-Villar M
Frontiers in immunology. 2022
PMID: 35603182
- Metabolomic and transcriptomic signatures of influenza vaccine response in healthy young and older adults.
Chou CH, Mohanty S, Kang HA, Kong L, Avila-Pacheco J, Joshi SR, Ueda I, Devine L, Raddassi K, Pierce K, Jeanfavre S, Bullock K, Meng H, Clish C, Santori FR, Shaw AC, Xavier RJ
Aging cell. 2022 Sep
PMID: 35996998
- Humoral Responses Against SARS-CoV-2 and Variants of Concern After mRNA Vaccines in Patients With Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia.
Chang A, Akhtar A, Linderman SL, Lai L, Orellana-Noia VM, Valanparambil R, Ahmed H, Zarnitsyna VI, McCook-Veal AA, Switchenko JM, Koff JL, Blum KA, Ayers AA, O'Leary CB, Churnetski MC, Sulaiman S, Kives M, Sheng P, Davis CW, Nooka AK, Antia R, Dhodapkar MV, Suthar MS, Cohen JB, Ahmed R
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2022 Sep 10
PMID: 35436146
- Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine.
Li C, Lee A, Grigoryan L, Arunachalam PS, Scott MKD, Trisal M, Wimmers F, Sanyal M, Weidenbacher PA, Feng Y, Adamska JZ, Valore E, Wang Y, Verma R, Reis N, Dunham D, O'Hara R, Park H, Luo W, Gitlin AD, Kim P, Khatri P, Nadeau KC, Pulendran B
Nature immunology. 2022 Apr
PMID: 35288714
- Determinants of Neutralizing Antibody Response After SARS CoV-2 Vaccination in Patients With Myeloma.
Nooka AK, Shanmugasundaram U, Cheedarla N, Verkerke H, Edara VV, Valanparambil R, Kaufman JL, Hofmeister CC, Joseph NS, Lonial S, Azeem M, Manalo J, Switchenko JM, Chang A, Linderman SL, Roback JD, Dhodapkar KM, Ahmed R, Suthar MS, Neish AS, Dhodapkar MV
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2022 Sep 10
PMID: 35259002
- Basic principles of neuroimmunology.
Yoshida TM, Wang A, Hafler DA
Seminars in immunopathology. 2022 Jun 22
PMID: 35732977
- A molecular atlas of innate immunity to adjuvanted and live attenuated vaccines, in mice.
Lee A, Scott MKD, Wimmers F, Arunachalam PS, Luo W, Fox CB, Tomai M, Khatri P, Pulendran B
Nature communications. 2022 Jan 27
PMID: 35087093
- Th2-Biased Transcriptional Profile Predicts HIV Envelope-Specific Polyfunctional CD4+ T Cells That Correlated with Reduced Risk of Infection in RV144 Trial.
Cohen KW, Tian Y, Thayer C, Seese A, Amezquita R, McElrath MJ, De Rosa SC, Gottardo R
Journal of immunology (Baltimore, Md. : 1950). 2022 Aug 1
PMID: 35803696
- A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy.
Ye L, Park JJ, Peng L, Yang Q, Chow RD, Dong MB, Lam SZ, Guo J, Tang E, Zhang Y, Wang G, Dai X, Du Y, Kim HR, Cao H, Errami Y, Clark P, Bersenev A, Montgomery RR, Chen S
Cell metabolism. 2022 Apr 5
PMID: 35276062
- Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells.
Sumida TS, Dulberg S, Schupp JC, Lincoln MR, Stillwell HA, Axisa PP, Comi M, Unterman A, Kaminski N, Madi A, Kuchroo VK, Hafler DA
Nature immunology. 2022 Apr
PMID: 35301508
- Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19.
Unterman A, Sumida TS, Nouri N, Yan X, Zhao AY, Gasque V, Schupp JC, Asashima H, Liu Y, Cosme C Jr, Deng W, Chen M, Raredon MSB, Hoehn KB, Wang G, Wang Z, DeIuliis G, Ravindra NG, Li N, Castaldi C, Wong P, Fournier J, Bermejo S, Sharma L, Casanovas-Massana A, Vogels CBF, Wyllie AL, Grubaugh ND, Melillo A, Meng H, Stein Y, Minasyan M, Mohanty S, Ruff WE, Cohen I, Raddassi K, Yale IMPACT Research Team., Niklason LE, Ko AI, Montgomery RR, Farhadian SF, Iwasaki A, Shaw AC, van Dijk D, Zhao H, Kleinstein SH, Hafler DA, Kaminski N, Dela Cruz CS
Nature communications. 2022 Jan 21
PMID: 35064122
- DestVI identifies continuums of cell types in spatial transcriptomics data.
Lopez R, Li B, Keren-Shaul H, Boyeau P, Kedmi M, Pilzer D, Jelinski A, Yofe I, David E, Wagner A, Ergen C, Addadi Y, Golani O, Ronchese F, Jordan MI, Amit I, Yosef N
Nature biotechnology. 2022 Apr 21
PMID: 35449415
- Peanut oral immunotherapy differentially suppresses clonally distinct subsets of T helper cells.
Monian B, Tu AA, Ruiter B, Morgan DM, Petrossian PM, Smith NP, Gierahn TM, Ginder JH, Shreffler WG, Love JC
The Journal of clinical investigation. 2022 Jan 18
PMID: 34813505
- Modular and mechanistic changes across stages of colorectal cancer.
Rahiminejad S, Maurya MR, Mukund K, Subramaniam S
BMC cancer. 2022 Apr 21
PMID: 35448980
- Multiscale PHATE identifies multimodal signatures of COVID-19.
Kuchroo M, Huang J, Wong P, Grenier JC, Shung D, Tong A, Lucas C, Klein J, Burkhardt DB, Gigante S, Godavarthi A, Rieck B, Israelow B, Simonov M, Mao T, Oh JE, Silva J, Takahashi T, Odio CD, Casanovas-Massana A, Fournier J, Yale IMPACT Team., Farhadian S, Dela Cruz CS, Ko AI, Hirn MJ, Wilson FP, Hussin JG, Wolf G, Iwasaki A, Krishnaswamy S
Nature biotechnology. 2022 May
PMID: 35228707
- Fighting the SARS-CoV-2 pandemic requires a global approach to understanding the heterogeneity of vaccine responses.
Tomalka JA, Suthar MS, Deeks SG, Sekaly RP
Nature immunology. 2022 Mar
PMID: 35210622
- Mouse-adapted SARS-CoV-2 protects animals from lethal SARS-CoV challenge.
Muruato A, Vu MN, Johnson BA, Davis-Gardner ME, Vanderheiden A, Lokugamage K, Schindewolf C, Crocquet-Valdes PA, Langsjoen RM, Plante JA, Plante KS, Weaver SC, Debbink K, Routh AL, Walker D, Suthar MS, Shi PY, Xie X, Menachery VD
PLoS biology. 2021 Nov
PMID: 34735434
- Cell-Mediated Immune Responses After Administration of the Live or the Recombinant Zoster Vaccine: 5-Year Persistence.
Johnson MJ, Liu C, Ghosh D, Lang N, Levin MJ, Weinberg A
The Journal of infectious diseases. 2022 Apr 19
PMID: 34850039
- A reservoir of stem-like CD8+ T cells in the tumor-draining lymph node preserves the ongoing antitumor immune response.
Connolly KA, Kuchroo M, Venkat A, Khatun A, Wang J, William I, Hornick NI, Fitzgerald BL, Damo M, Kasmani MY, Cui C, Fagerberg E, Monroy I, Hutchins A, Cheung JF, Foster GG, Mariuzza DL, Nader M, Zhao H, Cui W, Krishnaswamy S, Joshi NS
Science immunology. 2021 Oct
PMID: 34597124
- An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging.
Sayed N, Huang Y, Nguyen K, Krejciova-Rajaniemi Z, Grawe AP, Gao T, Tibshirani R, Hastie T, Alpert A, Cui L, Kuznetsova T, Rosenberg-Hasson Y, Ostan R, Monti D, Lehallier B, Shen-Orr SS, Maecker HT, Dekker CL, Wyss-Coray T, Franceschi C, Jojic V, Haddad F, Montoya JG, Wu JC, Davis MM, Furman D
Nature aging. 2021 Jul
PMID: 34888528
- Immune Response in Severe and Non-Severe Coronavirus Disease 2019 (COVID-19) Infection: A Mechanistic Landscape.
Mukund K, Nayak P, Ashokkumar C, Rao S, Almeda J, Betancourt-Garcia MM, Sindhi R, Subramaniam S
Frontiers in immunology. 2021
PMID: 34721400
- Alterations in high-dimensional T-cell profile and gene signature of immune aging in HIV-infected older adults without viremia.
Shin MS, Park HJ, Salahuddin S, Montgomery RR, Emu B, Shaw AC, Kang I
Aging cell. 2022 Aug 29
PMID: 36036630
- Durability of immune responses to the BNT162b2 mRNA vaccine.
Suthar MS, Arunachalam PS, Hu M, Reis N, Trisal M, Raeber O, Chinthrajah S, Davis-Gardner ME, Manning K, Mudvari P, Boritz E, Godbole S, Henry AR, Douek DC, Halfmann P, Kawaoka Y, Boyd SD, Davis MM, Zarnitsyna VI, Nadeau K, Pulendran B
Med (New York, N.Y.). 2022 Jan 14
PMID: 35590141
- PeakVI: A deep generative model for single-cell chromatin accessibility analysis.
Ashuach T, Reidenbach DA, Gayoso A, Yosef N
Cell reports methods. 2022 Mar 28
PMID: 35475224
- Tox2 is required for the maintenance of GC TFH cells and the generation of memory TFH cells.
Horiuchi S, Wu H, Liu WC, Schmitt N, Provot J, Liu Y, Bentebibel SE, Albrecht RA, Schotsaert M, Forst CV, Zhang B, Ueno H
Science advances. 2021 Oct 8
PMID: 34623911
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