Title: Bioinformatics Approach to Influenza A/H1N1 Vaccine Immune Profiling
PI: Gregory A. Poland
The HIPC Center at Mayo Clinic focuses on to creating comprehensive and innovative immune profiles utilizing systems biology and bioinformatics approaches that explain and predict variations in immune responses to influenza. These studies will characterize the human immune response before and after 2010-2011 influenza A/California/H1N1 seasonal vaccination among older adults, and will enable the discrimination of baseline versus early, mid, and late (homeostatic) innate, humoral, and cellular immune responses after immunization.
These studies will be the first systematic immune profiles and models of influenza A vaccine-specific immunogenicity using novel high dimensional technology and bioinformatics approaches, and have the potential to set the standard for analytical methods to understand complex biologic systems. Novel information describing how immune responses to inactivated influenza A/H1N1 vaccine are generated will be obtained and this information may be useful in designing new vaccines to control this deadly viral disease.
Bioinformatics Approach to Influenza A/H1n1 Vaccine Immune Profiling
Project Leader: Gregory Poland
Institution: Mayo Clinic