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About HIPC

The Human Immunology Project Consortium (HIPC) program was established in 2010, and renewed in 2015, by the NIAID Division of Allergy, Immunology, and Transplantation as part of the overall NIAID focus on human immunology. Through this program, well-characterized human cohorts are studied using a variety of modern analytic tools, including multiplex transcriptional, cytokine, and proteomic assays; multiparameter phenotyping of leukocyte subsets; assessment of leukocyte functional status; and multiple computational methods.

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  • Recent Publications

  • ImmuneSpace

    Immunespace is a major collaborative effort that is generating large amounts of cross-center and cross-assay data — including high-dimensional data — to characterize the status of the immune system in diverse populations under both normal conditions and in response to stimuli. This large data problem has given birth to ImmuneSpace, a powerful data management and analysis engine where datasets can be easily explored and analyzed using state-of-the-art computational tools.
  • HIPC Innate Immune Profiling Compendium

    The goal of the HIPC Innate Immune Profiling Compendium is to develop bioinformatics resources supporting the investigation of the role of the innate immune response in vaccine immunogenicity using blood transcriptome profiling data. This project will foster collaborative analytic projects within HIPC and develop publically available tools for large scale data analysis and dissemination

    The common denominators for this compendium are blood transcriptome profiling data but demographic, clinical and immune profiling data is incorporated as available. This context-rich data collection will be a resource for comparing responses obtained across a wide range of vaccines, adjuvants and infectious diseases.
  • HIPC Technologies

    HIPC investigators utilize cutting edge technologies to define immune signatures in healthy, vaccinated, and diseased states. These technologies include: quantitative gene expression platforms (Illumina, Affymetrix, Nanostring & RNAseq) for innate and adaptive immune response profiling; multiparameter blood cell subset analyses (phenotype & function, including PhosphoFlow); antibody binding/neutralization and repertoire analysis; cytokine and chemokine levels; high throughput HLA, Ig & TCR sequencing; and advanced mass spectrometry methods including highly sensitive epitope identification as well as the CyTOFTM approach, which combines flow cytometry with atomic mass spectrometry for detailed cellular analyses.

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